Production of homozygous klotho knockout porcine embryos cloned from genome-edited porcine fibroblasts

• Main Authors: Sanghoon Lee (Author), Min Hee Jung (Author), Hyun Ju Oh (Author), Ok Jae Koo (Author), Se Chang Park (Author), Byeong Chun Le (Author)
• Format: Book
• Published: The Korean Society of Animal Reproduction and Biotechnology, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Even though klotho deficiency in mice exhibits multiple aging-like phenotypes, studies using large animal models such as pigs, which have many similarities to humans, have been limited due to the absence of cell lines or animal models. The objective of this study was to generate homozygous klotho kn...