Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

• Main Authors: Francesca Ros (Author), Sonja Offner (Author), Stefan Klostermann (Author), Irmgard Thorey (Author), Helmut Niersbach (Author), Sebastian Breuer (Author), Grit Zarnt (Author), Stefan Lorenz (Author), Juergen Puels (Author), Basile Siewe (Author), Nicole Schueler (Author), Tajana Dragicevic (Author), Dominique Ostler (Author), Imke Hansen-Wester (Author), Valeria Lifke (Author), Brigitte Kaluza (Author), Klaus Kaluza (Author), Wim van Schooten (Author), Roland Buelow (Author), Alain C Tissot (Author), Josef Platzer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been established using mice, but also more recently rats, ch...