Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKβ Action in a Fiber-Type Specific Manner

• Main Authors: Benjamin T. Bikman (Author), Donghai Zheng (Author), Daniel A. Kane (Author), Ethan J. Anderson (Author), Tracey L. Woodlief (Author), Jesse W. Price (Author), G. Lynis Dohm (Author), P. Darrell Neufer (Author), Ronald N. Cortright (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) in this same tissue are unknown. The aim of this study was to (1) determine th...