Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

• Main Authors: Eric Sauvage (Author), Mohammed Terrak (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2016-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are essential for the s...