Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles

• Main Authors: Elsayed A. Elmorsy (Author), Sameh Saber (Author), Ahmed Y. Kira (Author), Abdullah Alghasham (Author), Mohamed R. Abdel-Hamed (Author), Maha M. Amer (Author), Enas A. Mohamed (Author), A AlSalloom A. (Author), Abdullah S. Alkhamiss (Author), Rabab S. Hamad (Author), Mustafa Ahmed Abdel-Reheim (Author), Abousree T. Ellethy (Author), Hossam A. Elsisi (Author), Mansour Alsharidah (Author), Sahar R. Elghandour (Author), Tayseer Elnawawy (Author), Rasha Abdelhady (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Liver fibrosis is a disease with a great global health and economic burden. Existing data highlights itraconazole (ITRCZ) as a potentially effective anti-fibrotic therapy. However, ITRCZ effect is hindered by several limitations, such as poor solubility and bioavailability. This study aimed to formu...