CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients

• Main Authors: Yilei Yang (Author), Xin Huang (Author), Yinping Shi (Author), Rui Yang (Author), Haiyan Shi (Author), Xinmei Yang (Author), Guoxiang Hao (Author), Yi Zheng (Author), Jianning Wang (Author), Lequn Su (Author), Yan Li (Author), Wei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The drug-drug interactions (DDIs) of tacrolimus greatly contributed to pharmacokinetic variability. Nifedipine, frequently prescribed for hypertension, is a competitive CYP3A5 inhibitor which can inhibit tacrolimus metabolism. The objective of this study was to investigate whether CYP3A5 ge...