Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

• المؤلفون الرئيسيون: Mica Ohara-Imaizumi (مؤلف), Kyota Aoyagi (مؤلف), Toshihisa Ohtsuka (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2019-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca2+-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into the vasculature has been proposed; however...