Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury

• Main Authors: Jingjing Cai (Author), Hua Zhong (Author), Jinze Wu (Author), Rui-Fang Chen (Author), Huan Yang (Author), Yousef Al-Abed (Author), Ying Li (Author), Xiaohui Li (Author), Weihong Jiang (Author), Marcelo F. Montenegro (Author), Hong Yuan (Author), Timothy R. Billiar (Author), Alex F. Chen (Author)
• Format: Book
• Published: BMC, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates processes leading to IH after arterial injury. Using a mouse model of wire-induced...