A composite nanocarrier to inhibit precipitation of the weakly basic drug in the gastrointestinal tract

• Main Authors: Chunli Zheng (Author), Yun Li (Author), Zhen Peng (Author), Xinyi He (Author), Juan Tao (Author), Liang Ge (Author), Yixin Sun (Author), Yunkai Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For weakly basic drugs, the sharp decrease of drug solubility and the following drug precipitation after drugs transferring from the gastric fluid to the intestinal fluid in the gastrointestinal (GI) tract is a main reason for the poor oral bioavailability of drugs. Here, an anticoagulant dabigatran...