miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

• Main Authors: Peng Xu (Author), Zhilang Li (Author), Yongqing Wang (Author), Xin Yu (Author), Xuan Shao (Author), Yu-xia Li (Author), Chun Peng (Author), Yangyu Zhao (Author), Yan-Ling Wang (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study investigated the regulation of Smad2 by miR-18a and its role in preeclampsia (PE). Bioinformatics analysis showed that both Smad2 and Smad3 were the predicted targets for miR-18a. Mass spectrum analysis showed that two mature Smad2 isoforms existed in human placenta: full length, Smad2(FL)...