Evaluation of the Anti-Tumor Activity of Small Molecules Targeting Eph/Ephrins in APC ^min/J Mice

• Main Authors: Miriam Corrado (Author), Carmine Giorgio (Author), Elisabetta Barocelli (Author), Giuseppe Vittucci Marzetti (Author), Anna Maria Cantoni (Author), Rosanna Di Lecce (Author), Matteo Incerti (Author), Riccardo Castelli (Author), Alessio Lodola (Author), Massimiliano Tognolini (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Eph receptors are the largest receptors tyrosine kinases (RTKs) family in humans and together with ephrin ligands constitute a complex cellular communication system often dysregulated in many tumors. The role of the Eph-ephrin system in colorectal cancer (CRC) has been investigated and different...