3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

• Main Authors: Milica Kosic (Author), Verica Paunovic (Author), Biljana Ristic (Author), Aleksandar Mircic (Author), Mihajlo Bosnjak (Author), Danijela Stevanovic (Author), Tamara Kravic-Stevovic (Author), Vladimir Trajkovic (Author), Ljubica Harhaji-Trajkovic (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respiration by rotenone. 2DG/rotenone reduced ATP levels...