Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

• Main Authors: Damon T. Jacobs (Author), Luciane M. Silva (Author), Bailey A. Allard (Author), Michael P. Schonfeld (Author), Anindita Chatterjee (Author), George C. Talbott (Author), David R. Beier (Author), Pamela V. Tran (Author)
• Format: Book
• Published: The Company of Biologists, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease and obesity. THM1 (also termed TTC21B or IFT139) enc...