Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

• Egile Nagusiak: Ivan O. Maslov (Egilea), Tatiana V. Zinevich (Egilea), Olga G. Kirichenko (Egilea), Mikhail V. Trukhan (Egilea), Sergey V. Shorshnev (Egilea), Natalya O. Tuaeva (Egilea), Maxim A. Gureev (Egilea), Amelia D. Dahlén (Egilea), Yuri B. Porozov (Egilea), Helgi B. Schiöth (Egilea), Vladimir M. Trukhan (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl peptidase-4) inhibitors. Compound <b>12a</b&g...