Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl peptidase-4) inhibitors. Compound <b>12a</b&g...

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Main Authors: Ivan O. Maslov (Author), Tatiana V. Zinevich (Author), Olga G. Kirichenko (Author), Mikhail V. Trukhan (Author), Sergey V. Shorshnev (Author), Natalya O. Tuaeva (Author), Maxim A. Gureev (Author), Amelia D. Dahlén (Author), Yuri B. Porozov (Author), Helgi B. Schiöth (Author), Vladimir M. Trukhan (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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