Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism

• Main Authors: Hwan-Jin Hwang (Author), Joo Won Kim (Author), Hye Soo Chung (Author), Ji A. Seo (Author), Sin Gon Kim (Author), Nan Hee Kim (Author), Kyung Mook Choi (Author), Sei Hyun Baik (Author), Hye Jin Yoo (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosph...