Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Hlavní autoři: Ernesto Callegari (Autor), Jian Lin (Autor), Susanna Tse (Autor), Theunis C. Goosen (Autor), Vaishali Sahasrabudhe (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2021-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...