Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Prif Awduron: Ernesto Callegari (Awdur), Jian Lin (Awdur), Susanna Tse (Awdur), Theunis C. Goosen (Awdur), Vaishali Sahasrabudhe (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Wiley, 2021-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...