Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Egile Nagusiak: Ernesto Callegari (Egilea), Jian Lin (Egilea), Susanna Tse (Egilea), Theunis C. Goosen (Egilea), Vaishali Sahasrabudhe (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2021-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...