Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Asıl Yazarlar: Ernesto Callegari (Yazar), Jian Lin (Yazar), Susanna Tse (Yazar), Theunis C. Goosen (Yazar), Vaishali Sahasrabudhe (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2021-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...