Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression

• Main Authors: Anton V. Malyshev (Author), Iuliia A. Sukhanova (Author), Valeria M. Ushakova (Author), Yana A. Zorkina (Author), Olga V. Abramova (Author), Anna Y. Morozova (Author), Eugene A. Zubkov (Author), Nikita A. Mitkin (Author), Vsevolod V. Pavshintsev (Author), Igor I. Doronin (Author), Vasilina R. Gedzun (Author), Gennady A. Babkin (Author), Sergio A. Sanchez (Author), Miah D. Baker (Author), Colin N. Haile (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously described the LCGA-17 peptide as a novel anxiolytic and antidepressant candidate that acts through the α2δ VGCC (voltage-gated calcium channel) subunit with putative synergism with GABA-A receptors. The current study tested the potential efficacy of acute and chronic intranasal (i...