Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells

• Main Authors: Homood M. As Sobeai (Author), Munirah Alohaydib (Author), Ali R. Alhoshani (Author), Khalid Alhazzani (Author), Mashal M. Almutairi (Author), Tareq Saleh (Author), David A. Gewirtz (Author), Moureq R. Alotiabi (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity. Promising new drugs named senolytics selectively target senescent cells and commit them into apoptosis. Accordingly, senol...