Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides

• Main Authors: Brian R. Anderson (Author), Marianne L. Jensen (Author), Peter H. Hagedorn (Author), Sean C. Little (Author), Richard E. Olson (Author), Ron Ammar (Author), Bernadette Kienzle (Author), John Thompson (Author), Ivar McDonald (Author), Stephen Mercer (Author), Jonas Vikesaa (Author), Bettina Nordbo (Author), Larry Iben (Author), Yang Cao (Author), Joanne Natale (Author), Greg Dalton-Kay (Author), Angela Cacace (Author), Bo R. Hansen (Author), Maj Hedtjärn (Author), Troels Koch (Author), Linda J. Bristow (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeutic feasibility of treating this diverse genetic population,...