Drug binding and drug-drug interaction considerations in individuals with obesity before and after bariatric surgery: A retrospective cross-sectional study

• Main Authors: Emerita Quintina de Andrade Moura (Author), Carolina Dumke de Siqueira (Author), Ana Carolina Martins (Author), Bruno Fonseca Nunes (Author), Ana Carolina Rabello de Moraes (Author), Fabíola Branco Filippin-Monteiro (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity impacts pharmacokinetic and pharmacodynamic parameters, changing the drug-binding state via plasma proteins, which is critical for drug effectiveness and toxicity. Albumin and α1-acid glycoprotein (AAG) are the two main proteins accountable for drug binding in humans. Previous studies have s...