Drug binding and drug-drug interaction considerations in individuals with obesity before and after bariatric surgery: A retrospective cross-sectional study

• 主要な著者: Emerita Quintina de Andrade Moura (著者), Carolina Dumke de Siqueira (著者), Ana Carolina Martins (著者), Bruno Fonseca Nunes (著者), Ana Carolina Rabello de Moraes (著者), Fabíola Branco Filippin-Monteiro (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Obesity impacts pharmacokinetic and pharmacodynamic parameters, changing the drug-binding state via plasma proteins, which is critical for drug effectiveness and toxicity. Albumin and α1-acid glycoprotein (AAG) are the two main proteins accountable for drug binding in humans. Previous studies have s...