Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

• Main Authors: Emna Harigua-Souiai (Author), Yosser Zina Abdelkrim (Author), Imen Bassoumi-Jamoussi (Author), Ons Zakraoui (Author), Guillaume Bouvier (Author), Khadija Essafi-Benkhadir (Author), Josette Banroques (Author), Nathan Desdouits (Author), Hélène Munier-Lehmann (Author), Mourad Barhoumi (Author), N Kyle Tanner (Author), Michael Nilges (Author), Arnaud Blondel (Author), Ikram Guizani (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4A (LieIF), an essential translation initiation fac...