Intrathecal Treatment With 6-Hydroxydopamine or 5,7-Dihydroxytryptamine Blocks the Antinociception Induced by Endomorphin-1 and Endomorphin-2 Given Intracerebroventricularly in the Mouse

• Main Authors: Kuei-chun Hung (Author), Hsiang-en Wu (Author), Hirokazu Mizoguchi (Author), Randy Leitermann (Author), Leon F. Tseng (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: The involvement of spinopetal noradrenergic and serotonergic systems in antinociception induced by endomorphin-1 (EM-1) and endomorphin-2 (EM-2) given supraspinally or spinally were investigated in male CD-1 mice. Groups of mice were pretreated intrathecally (i.t.) with 6-hydroxydopamine (...