Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells

Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells

Androgen receptor (AR) signaling is fundamental to prostate cancer (PC) progression, and hence, androgen deprivation therapy (ADT) remains a mainstay of treatment. However, augmented AR signaling via both full length AR (AR-FL) and constitutively active AR splice variants, especially AR-V7, is assoc...

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Main Authors: Namrata Khurana (Author), Partha K. Chandra (Author), Hogyoung Kim (Author), Asim B. Abdel-Mageed (Author), Debasis Mondal (Author), Suresh C. Sikka (Author)
Format: Book
Published: MDPI AG, 2020-01-01T00:00:00Z.
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