A Bayesian framework for virtual comparative trials and bioequivalence assessments
IntroductionIn virtual bioequivalence (VBE) assessments, pharmacokinetic models informed with in vitro data and verified with small clinical trials' data are used to simulate otherwise unfeasibly large trials. Simulated VBE trials are assessed in a frequentist framework as if they were real des...
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Frontiers Media S.A.,
2024-07-01T00:00:00Z.
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