Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

• Asıl Yazarlar: Hong Shen (Yazar), Lifei Wang (Yazar), Weiqi Chen (Yazar), Krista Menard (Yazar), Yang Hong (Yazar), Yuan Tian (Yazar), Samuel J. Bonacorsi (Yazar), W. Griffith Humphreys (Yazar), Francis Y. Lee (Yazar), Jinping Gan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2016-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR- tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and LC-MS/MS following i.v. administration of BMS-75349...