Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

• Main Authors: Calvin Dunker (Author), Lukas Imberg (Author), Alena I. Siutkina (Author), Catharina Erbacher (Author), Constantin G. Daniliuc (Author), Uwe Karst (Author), Dmitrii V. Kalinin (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological activity of a series of 1<i>H</i>-pyr...