Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

• Main Authors: Yu Song (Author), Wenying Zan (Author), Liping Qin (Author), Shuang Han (Author), Lili Ye (Author), Molin Wang (Author), Baichun Jiang (Author), Pan Fang (Author), Qiji Liu (Author), Changshun Shao (Author), Yaoqin Gong (Author), Peishan Li (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index. However, the precise biological roles of ORMDL3 in obesity and lipid metabolism remain uncharacterized. Here, we investigate the function of ORM...