Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart

• Main Authors: Xiaochen Li (Author), Cheng Meng (Author), Fei Han (Author), Juhong Yang (Author), Jingyu Wang (Author), Yanjuan Zhu (Author), Xiao Cui (Author), Minxia Zuo (Author), Jie Xu (Author), Baocheng Chang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development of diabetic cardiomyopathy in type 2 diabetic mice and identify i...