Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew)

• Päätekijät: John A. Rudd (Tekijä), Sze W. Chan (Tekijä), Man P. Ngan (Tekijä), Longlong Tu (Tekijä), Zengbing Lu (Tekijä), Claudio Giuliano (Tekijä), Emanuela Lovati (Tekijä), Claudio Pietra (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Ghrelin has well-known activity to stimulate appetite and weight gain. Evidence suggests that ghrelin may also have effects in reducing chemotherapy-induced emesis via growth hormone secretagogue receptors (GHS-R1A) in the brain. However, it is not known whether the stimulation of GHS-R1A has broad...