A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial.

• Main Authors: Anna P Durbin (Author), Stephen S Whitehead (Author), Donna Shaffer (Author), Dan Elwood (Author), Kimberli Wanionek (Author), Bhavin Thumar (Author), Joseph E Blaney (Author), Brian R Murphy (Author), Alexander C Schmidt (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue is an emerging infectious disease that has become the most important arboviral infection worldwide. There are four serotypes of dengue virus, DENV-1, DENV-2, DENV-3, and DENV-4, each capable of causing the full spectrum of disease. rDEN1Δ30 is a live attenuated investigational vaccine for the...