The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability

• Main Authors: Giovanna Rassu (Author), Luca Ferraro (Author), Barbara Pavan (Author), Paolo Giunchedi (Author), Elisabetta Gavini (Author), Alessandro Dalpiaz (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microspheres based on both methyl-β-cyclodextrins and chitosan were prepared by spray-drying as nasal formulations of a model polar drug to analyze, firstly, how the composition of the carrier affects drug permeation across synthetic membranes and, secondly, how it induces systemic or brain...