Quinazolin-4(3H)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity

• Main Authors: Tebyan O. Mirgany (Author), Ashraf N. Abdalla (Author), Md Arifuzzaman (Author), A. F. M. Motiur Rahman (Author), Huda S. Al-Salem (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

A series of quinazolin-4(3H)-one derivatives were synthesised and evaluated for their cytotoxicity against human Caucasian breast adenocarcinoma (MCF-7) and human ovarian carcinoma (A2780) cell lines. Cytotoxicity of the most tested compounds was 2- to 30-fold more than the positive control lapatini...