Quinazolin-4(3H)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity

• Principais autores: Tebyan O. Mirgany (Autor), Ashraf N. Abdalla (Autor), Md Arifuzzaman (Autor), A. F. M. Motiur Rahman (Autor), Huda S. Al-Salem (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A series of quinazolin-4(3H)-one derivatives were synthesised and evaluated for their cytotoxicity against human Caucasian breast adenocarcinoma (MCF-7) and human ovarian carcinoma (A2780) cell lines. Cytotoxicity of the most tested compounds was 2- to 30-fold more than the positive control lapatini...