miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells

• Main Authors: Zhi Xu (Author), Yanyan Zhang (Author), Jiaji Ding (Author), Weizi Hu (Author), Chunli Tan (Author), Mei Wang (Author), Jinhai Tang (Author), Yong Xu (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radioresistance remains to be a major obstacle in the management of patients with advanced prostate cancer (PCa). We have identified a mature miR-17-3p processed from the 3' arm of precursor miR-17, which appeared to be able to inhibit three major antioxidant enzymes located in mitochondria, i....