Motor neuron degeneration correlates with respiratory dysfunction in SCA1

• Päätekijät: James P. Orengo (Tekijä), Meike E. van der Heijden (Tekijä), Shuang Hao (Tekijä), Jianrong Tang (Tekijä), Harry T. Orr (Tekijä), Huda Y. Zoghbi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2018-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Spinocerebellar ataxia type 1 (SCA1) is characterized by adult-onset cerebellar degeneration with attendant loss of motor coordination. Bulbar function is eventually impaired and patients typically die from an inability to clear the airway. We investigated whether motor neuron degeneration is at the...