Activin A Modulates CRIPTO-1/HNF4α+ Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells

• Main Authors: Robin Duelen (Author), Guillaume Gilbert (Author), Abdulsamie Patel (Author), Nathalie de Schaetzen (Author), Liesbeth De Waele (Author), Llewelyn Roderick (Author), Karin R. Sipido (Author), Catherine M. Verfaillie (Author), Gunnar M. Buyse (Author), Lieven Thorrez (Author), Maurilio Sampaolesi (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of human pluripotent stem cells in basic and translational cardiac research requires efficient differentiation protocols towards cardiomyocytes. In vitro differentiation yields heterogeneous populations of ventricular-, atrial-, and nodal-like cells hindering their potential applications in...