Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials

• Main Authors: Chen Chaoyang (Author), Dong Xiu (Author), Wei Ran (Author), Ma Lingyun (Author), Zhao Simiao (Author), Li Ruoming (Author), Zhang Enyao (Author), Zhou Ying (Author), Cui Yimin (Author), Liu Zhenming (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: This study aimed to investigate the pharmacokinetic characteristics of siponimod in healthy volunteers and patients with MS based on aggregated data from published clinical trials, and to explore the factors influencing siponimod exposure.Methods: A total of 476 siponimod plasma concentr...