The use of splenectomy to manage platelet transfusion refractoriness due to anti-human leukocyte antibodies in allogeneic stem cell transplantation

• Main Authors: Margherita Mauro (Author), Francesco Camoglio (Author), Pierluigi Piccoli (Author), Massimiliano De Bortoli (Author), Rita Balter (Author), Anna Pegoraro (Author), Simone Cesaro (Author)
• Format: Book
• Published: MDPI AG, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival. Therapeutic strategies include plasma exchange, immunoglobulins, rituximab, and s...