Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis

• Главные авторы: Miia Perälä (Автор), Meri Kaustio (Автор), Alexander Salava (Автор), Eveliina Jakkula (Автор), Anna S. Pelkonen (Автор), Janna Saarela (Автор), Anita Remitz (Автор), Mika J. Mäkelä (Автор)
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• Опубликовано: Elsevier, 2023-07-01T00:00:00Z.
• Предметы: article
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Early-onset, persistent atopic dermatitis (AD) is proposed as a distinct subgroup that may have specific genotypic features. FLG gene loss-of-function variants are the best known genetic factors contributing to epidermal barrier impairment and eczema severity. In a cohort of 140 Finnish children wit...