Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway

• Main Authors: Jiao Huang (Author), Yang Zhao (Author), Xi Luo (Author), Yunpeng Luo (Author), Jiemei Ji (Author), Jia Li (Author), Jian Lai (Author), Ziru Liu (Author), Yuanyuan Chen (Author), Yunan Lin (Author), Jingchen Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives The molecular mechanism underlying the protective effects of DEX against sepsis-induced acute kidney injury (SAKI) remains to be elucidated.Methods We established S-AKI models in vivo via CLP and in vitro with LPS-induced HK-2 cells.Results The Nrf2/SLC7A11/FSP1/CoQ10 pathway was inhibite...