Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma

• Main Authors: Dan Han (Author), Qiannan Ma (Author), Petek Ballar (Author), Chunyang Zhang (Author), Min Dai (Author), Xiaoyuan Luo (Author), Jiong Gu (Author), Chuansheng Wei (Author), Panhui Guo (Author), Lulu Zeng (Author), Min Hu (Author), Can Jiang (Author), Yanyan Liang (Author), Yanyan Wang (Author), Chao Hou (Author), Xian Wang (Author), Lijie Feng (Author), Yujun Shen (Author), Yuxian Shen (Author), Xiangpeng Hu (Author), Jun Liu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In advanced hepatocellular carcinoma (HCC) tissues, M2-like tumor-associated macrophages (TAMs) are in the majority and promotes HCC progression. Contrary to the pro-tumor effect of M2-like TAMs, M1-like TAMs account for a small proportion and have anti-tumor effects. Since TAMs can switch from one...