Design, Synthesis and In Vitro Antimicrobial Activity of 6-(1<i>H</i>-Benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-thio-3,4-dihydrothieno[2,3-<i>d</i>]pyrimidines

• Príomhchruthaitheoirí: Sergiy V. Vlasov (Údar), Olena D. Vlasova (Údar), Hanna I. Severina (Údar), Konstantin Yu. Krolenko (Údar), Oleksandr V. Borysov (Údar), Amjad Ibrahim M. Abu Sharkh (Údar), Vitaliy S. Vlasov (Údar), Victoriya A. Georgiyants (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2021-11-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

The rapid development in bacterial resistance to many groups of known antibiotics forces the researchers to discover antibacterial drug candidates with previously unknown mechanisms of action, one of the most relevant being the inhibition of tRNA (Guanine37-N1)-methyltransferase (TrmD). The discover...