A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

• Main Authors: Dikan Wang (Author), Juan Fang (Author), Shuqiong Wen (Author), Qunxing Li (Author), Jinming Wang (Author), Lisa Yang (Author), Wenxiao Dai (Author), Huanzi Lu (Author), Junyi Guo (Author), Zhongyan Shan (Author), Wenqiang Xie (Author), Xiangqi Liu (Author), Liling Wen (Author), Jie Shen (Author), Anxun Wang (Author), Qianming Chen (Author), Zhi Wang (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The heterogeneity of exhausted T cells (Tex) is a critical determinant of immune checkpoint blockade therapy efficacy. However, few studies have explored exhausted T cell subpopulations in human cancers. In the present study, we examined samples from two cohorts of 175 patients with head an...