CV-159, a Unique Dihydropyridine Derivative, Prevents TNF-Induced Inflammatory Responses in Human Umbilical Vein Endothelial Cells

• Main Authors: Tatsuya Usui (Author), Hideyuki Yamawaki (Author), Masato Kamibayashi (Author), Muneyoshi Okada (Author), Yukio Hara (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CV-159, a 1,4-dihydropyridine derivative, has Ca2+antagonistic and anti-calmodulin actions. An early feature of atherosclerosis is vascular endothelial inflammatory change. We examined whether CV-159 has protective effects against endothelial inflammatory responses. After pretreatment of human umbil...