Optimal KI Prophylactic Dose Determination for Thyroid Radiation Protection After a Single Administration in Adult Rats

• Main Authors: Guillaume Phan (Author), François Rebière (Author), David Suhard (Author), Alexandre Legrand (Author), Floriane Carpentier (Author), Thibaud Sontag (Author), Maâmar Souidi (Author), Jean-René Jourdain (Author), Michelle Agarande (Author), Valérie Renaud-Salis (Author)
• Format: Book
• Published: SAGE Publishing, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A dose-response study was performed in adult rats to select an optimal stable potassium iodide (KI) dose which could be implemented in repeated prophylaxis, in case of prolonged exposure to radioactive iodine. Increasing doses of KI were given orally to rats 1 hour before internal exposure simulated...