Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling

• Main Authors: Jingyi Li (Author), Chengcheng Niu (Author), Zichao Jiang (Author), Zhen Zhang (Author), Yixiao Pan (Author), Qiqi Xing (Author), Qi Guo (Author), Senbo An (Author), Yihe Hu (Author), Long Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel d...