A bioluminescent imaging mouse model for Marburg virus based on a pseudovirus system

• Main Authors: Li Zhang (Author), Qianqian Li (Author), Qiang Liu (Author), Weijin Huang (Author), Jianhui Nie (Author), Youchun Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Marburg virus (MARV) can cause lethal hemorrhagic fever in humans. Handling of MARV is restricted to high-containment biosafety level 4 (BSL-4) facilities, which greatly impedes research into this virus. In this study, a high titer of MARV pseudovirus was generated through optimization of the HIV ba...