Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway

• Main Authors: Sara Ilari (Author), Luigino Antonio Giancotti (Author), Filomena Lauro (Author), Micaela Gliozzi (Author), Valentina Malafoglia (Author), Ernesto Palma (Author), Marco Tafani (Author), Matteo Antonio Russo (Author), Carlo Tomino (Author), Massimo Fini (Author), Daniela Salvemini (Author), Vincenzo Mollace (Author), Carolina Muscoli (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen species (ROS) are implicated in chronic pain. Particularly, the enhanced ROS production alters the mitochondrial genome and proteome through the accumulation of lipid peroxidation products, such as 4-hydroxynonenal (...